Influence of Implant Site on the Immunologic Response of Unconditioned Syrian Hamsters to Heterotransplantable Human Tumors.

2 Present address : Department of Viral Oncology, Roswell Park Memorial Institute, Buffalo, New York. Received for publication November 20, 1964. i.m. sites, even though primary implants grew in the latter 3 sites for 1—3weeks. This observation supports the con cept that the hamster pouch is an immunologically privi leged site similar to the anterior chamber of the eye and the brain (5, 6). The exact mechanism which confers im munologic privilege on the pouch is not known, although direct evidence that hamster cheek pouch skin functions as a selective immunologic barrier has been presented by Bilhingham and Silvers (2). These workers increased the longevity of normal ear skin grafts 2—5times by interpos